Gender and Sodium-Ascorbate Transporter Isoforms Determine Ascorbate Concentrations in Mice
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منابع مشابه
Sodium-ascorbate cotransport controls intracellular ascorbate concentration in primary astrocyte cultures expressing the SVCT2 transporter.
Expression of the Na(+)-ascorbate cotransporter, SVCT2, was detected in rat brain and in primary cultures of cerebral astrocytes by Northern blot analysis. SVCT2 expression in cultured astrocytes increased in response to the cyclic AMP analog, dibutyryl cyclic AMP. A mathematical model of ascorbic acid transport was developed to evaluate the hypothesis that Na(+)-ascorbate cotransport across th...
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The mode of coordination of8 manganese(fI), cobaltm, nickel(H), copper(II), zinc(H), lead(II) and cadmium(I1) to sodium ascorbate (NaHAsc) was investigated using IR, UV-visible, AAS, elemental microanalyzer, conductivity, magnetic and 'M and I3C NMR spectroscopic studies, NaNAsc is bidentate and coordination was through the carbonyl group and the oxygen atom of carbon-2 enolic hydfoxyl grou...
متن کاملAscorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo.
Ascorbate (ascorbic acid, vitamin C), in pharmacologic concentrations easily achieved in humans by i.v. administration, selectively kills some cancer cells but not normal cells. We proposed that pharmacologic ascorbate is a prodrug for preferential steady-state formation of ascorbate radical (Asc(*-)) and H(2)O(2) in the extracellular space compared with blood. Here we test this hypothesis in v...
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The sgaTBA genes of Escherichia coli encode a putative 12-transmembrane alpha-helical segment (12 TMS) transporter, an enzyme IIB-like protein and an enzyme IIA-like protein of the phosphotransferase system (PTS), respectively. We show that all three proteins as well as the energy-coupling PTS proteins, enzyme I and HPr, are required for the anaerobic utilization and uptake of L-ascorbate in vi...
متن کاملPolymorphisms in the sodium-dependent ascorbate transporter gene SLC23A1 are associated with susceptibility to Crohn disease.
BACKGROUND Crohn disease (CD) and ulcerative colitis (UC) are 2 common inflammatory bowel diseases (IBDs) associated with intestinal inflammation and tissue damage. Oxidative stress is suggested to play a major role in the initiation and progression of IBD. Vitamin C (ascorbate, ascorbic acid) supplementation has reduced oxidative stress in persons with IBD. The role of ascorbate transporters i...
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ژورنال
عنوان ژورنال: The Journal of Nutrition
سال: 2004
ISSN: 0022-3166,1541-6100
DOI: 10.1093/jn/134.9.2216